Danger! (2) Maleic anhydride has an acrid odor, with an odor threshold of 0.32 parts per million (ppm). Move out of dangerous area. Causes skin burns. May cause conjunctivitis. Safety Statements :26-36/37/39 Causes eye burns. Immediate medical attention is required. [Note: Reacts slowly with water (hydrolyzes) to form maleic acid. Maleic anhydride, polymers Safety Profile. Consult a physician. Maleic anhydride has several uses, almost all of them related to the synthesis of other chemicals as fumaric and tartaric acids, certain agricultural chemicals (i.e., maleic hydrazide, malathion), lubricants, surface active agents, resins in different products, dye intermediates, pharmaceuticals, and more. : 607-096-00-9 CAS-No. Maleic anhydride released into water will hydrolyze rapidly (half-life 0.37 min) to maleic acid. Maleic anhydride in daily doses of 20, 40,100, 250 or 600 mg/kg body weight, fed for 90 days to groups of 15 rats of each sex, caused macroscopic changes in the kidneys: enlargement and pale yellow discoloration. Causes severe eye and skin irritation with possible Reproductive Toxicity: No data available Reproductive toxicity - Rat - Oral Moisture sensitive. System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Urinary: 1 x 10 -1: Renal lesions: NOAEL : 1.0 x 10 1 mg/kg-day Product Identification Synonyms: cis-Butenedioic anhydride; 2,5-furandione; toxilic anhydride CAS No. Appearance: white lumps. exposure may cause allergic respiratory reaction (asthma). burns. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. EC -No. ... Maleic anhydride is transported also as hot liquid (70°C); contact of the skin should be avoided. Maleic anhydride is used in the formulation of resins. Ingestion: +86-532-8027466 SECTION 1: PRODUCT AND COMPANY IDENTIFICATION ... Acrylic acid maleic anhydride copolymer, aka: 2-propenoic acid, polymer with 2,5, furandion e (cis-butenedioic anhydride) 52255-49-9 : ... Acrylic Acid Maleic … Chem., 1979, 179, C19], and is considered an excellent dieneophile for Diels-Alder reactions [Felthouse, Timothy R. et al. Evaporate the chloroform in a hood. MATERIAL SAFETY DATA SHEET MALEIC ANHYDRIDE 1. Strong oxidizers, water, alkalis, metals, caustics & amines above 150°F (5,8) The vapor pressure for maleic anhydride is 0.1 to 0.2 mm Hg at 25 °C. Histological examination revealed nephrosis which increased in severity with the dose above 100 mg/kg. Substance Any concentration shown as a range is to protect confidentiality or is due to batch variation. Causes gastrointestinal tract burns. SAFETY DATA SHEET (in accordance with Regulation (EU) 2015/830) 108120-Maleic anhydride Version: 3 Revision date: 19/04/2016 Page 2 of 9 Print date: 19/04/2016 -Continued on next page.- P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. 1272/2008, Regulation (EC) No.1907/2006 Maleic Anhydride, rev 2 7/2012 Page 2 Basis for Classification This substance is classified based on Directive 1272/2008/EC and its amendments (CLP Regulation,GHS) MALEIC ANHYDRIDE (108-31-6) A combination of these processes should be important. Recrystallize the maleic anhydride from toluene. Maleic Anhydride 95 - 100% 108-31-6 Get medical attention immediately. Remove victim to fresh Causes redness and Inhalation: Symptoms and effects are not known to date. Chronic: First Aid Measures Description of Firstaid Measures General Advice: Consult a physician. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 INDIA Chemical safety data sheet sd-88: properties and essential information for safe handling and use of maleic anhydride. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in … Maleic acid 110-16-7 >95 4. irritation with nausea, vomiting, and diarrhea. Show this safety data sheet to the doctor in attendance. CDC twenty four seven. Maleic Anhydride Flinn Scientific, Inc. P.O. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Maleic anhydride CAS -No. : 108-31-6 Molecular Weight: 98.06 Chemical Formula: C4H2O3 Company: ADDTEK CHEMICAL SHANGHAI CO LTD TEL: +86 21 63352916 FAX: +86 21 51010033EXT8839 OSHA Vacated PELs: Acetic anhydride: No OSHA Vacated PELs are listed for this chemical. Causes redness and pain. Show this safety data sheet to the doctor in attendance.Move out of dangerous area. If not breathing, give artificial respiration. May cause digestive tract A poison by intravenous route. May cause asthmatic attacks due to allergic sensitization of the Product name : Maleic anhydride Product Number : 63200 Brand : Sigma-Aldrich Index-No. Causes chemical burns to the respiratory tract. The anhydride of maleic acid has five atoms in its cyclic molecule, the unsaturated bond undergoes free radical polymerization in the presence of an initiator. Add 0.98 g (0.01 mole) of maleic anhydride to a solution of 1.67 g (0.01 mole) of veratrylamine in 10 mL of chloroform. Maleic anhydride TWA: 0.01 mg/m 3(Vacated) TWA: 0.25 ppm (Vacated) TWA: 1 mg/m3 TWA: 0.25 ppm TWA: 1 mg/m3 IDLH: 10 mg/m TWA: 0.25 ppm TWA: 1 mg/m3 TWA: 0.01 ppm Legend ACGIH - American Conference of Governmental Industrial Hygienists OSHA - Occupational Safety and … Interagency Collaborative Group on Environmental Carcinogens. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. MCA [1974]. Target Organs: Lungs, respiratory system, eyes, Product name : Maleic Anhydride CAS-No. If inhaled If breathed in, move person into fresh air. Skin: Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), National Institute for Occupational Safety and Health, A – NIOSH Potential Occupational Carcinogens, E – OSHA Respirator Requirements for Selected Chemicals, G – 1989 Air Contaminants Update Project: Exposure Limits NOT in Effect, Type C & CE – Definitions for Type C and Type CE Respirators, U.S. Department of Health & Human Services. Harmful if swallowed. 6. Prolonged or repeated skin contact may cause dermatitis. Environmental: Maleic anhydride's fate in soil is unknown. The odour warning when the exposure limit value is exceeded is insufficient. Combustible Solid, but may be difficult to ignite. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. Inhalation of high concentrations may cause pulmonary edema. Washington, DC: Manufacturing Chemists Association, p. 1-13. Maleic anhydride undergoes a potentially explosive exothermic Diels-Alder reaction with 1-methylsilacyclopenta-2,4-diene at 150C [Barton, T. J., J. Organomet. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. reaction, which becomes evident upon re-exposure to this material. Chemical name :maleic anhydride Substance/mixture : Occupational exposure limits, if available, are listed in Section 8. National Cancer Institute, June 17, 1974. 108 -31 -6 203 -571 -6 607 -096 -00 -9 - 4. Box 219, Batavia, IL 60510 (800) 452-1261 Chemtrec Emergency Phone Number: (800) 424-9974 tract irritation and possible burns. Common Name Maleic Anhydride Synonym(s) 2,5Furandione Formula C 4 H 2 O 3 CAS Number 108316 COMPONENT CAS NUMBER CONCENTRATION Maleic Anhydride 108316 ≤ Section 4. safety hazards of Maleic Acid to potentially exposed workers. Eye: Environmental: Maleic anhydride's fate in soil is unknown. respiratory tract. You will be subject to the destination website's privacy policy when you follow the link. : 108-31-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 1.3 Details of the supplier of the safety data sheet May cause skin sensitization, an allergic Up to 10 mg/m3: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode£(APF = 50) Any self-contained breathing apparatus with a full facepiece(APF = 50) Any supplied-air respirator with a full facepiece, Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus, Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having an N100, R100, or P100 filter. : 108-31-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. Index -No. Safety Data Sheet (Maleic Anhydride) DATE PREPARED: 9/3/2015 Page 7 of 9 OSHA: No component of this product, present at levels greater than or equal to 0.1%, is identified as a carcinogen or potential carcinogen by OSHA. Colorless needles, white lumps, or pellets with an irritating, choking odor. May cause blistering of the skin. Wash out mouth with water. Acute (short-term) inhalation exposure of humans to maleic anhydride has been observed to cause irritation of the respiratory tract and eye irritation. Pesticide properties for Maleic hydrazide, including approvals, environmental fate, eco-toxicity and human health issues Repeated Dissolve the residue in a minimal amount of chloroform. Product identifier Identification number Name of the substance Maleic anhydride 607-096-00-9 (Index number) Registration number 01-2119472428-31 Synonyms MAN Issue date 07-March-2019 Version number 01 Revision date-Supersedes date-1.2. cis-Butenedioic anhydride, 2,5-Furanedione, Maleic acid anhydride, Toxilic anhydride Colorless needles, white lumps, or pellets with an irritating, choking odor. Memorandum. Safety Data Sheet 24 hour Emergency Response No. (2) Conversion Factors: Hazard classification & labelling Hazard classification and labelling. Anhydrides. ], inhalation, ingestion, skin and/or eye contact, irritation nose, upper respiratory system; conjunctivitis; photophobia (abnormal visual intolerance to light), double vision; bronchial asthma; dermatitis, Centers for Disease Control and Prevention. Exposure to high fume concentrations cause photophobia, FIRST AID MEASURES General advice Consult a physician. Causes respiratory May cause allergic skin and respiratory reaction. NCI [1974]. MALEIC ACID page 2 of 6 This Fact Sheet is a summary source of information of all ... (as Maleic Anhydride) exists, use a MSHA/NIOSH approved self-contained breathing apparatus with a full facepiece operated in a … Maleic Anhydride Safety Data Sheet International Diol Company SAFETY DATA SHEET according to Regulation (EC) No. pain. Wear safety goggles or eye protection in combination with breathing protection if powder. Harmful if swallowed. Maleic anhydride is a colorless to white solid that forms orthorhombic crystals and decomposes in water. Polynt Group produces a great variety of anhydrides, but the most important ones are: Phthalic Anhydrides, Maleic Anhydride, Trimellitic Anhydride Rinse mouth with water (only if the person is conscious). Risk Statements: 36/37/38 R36/37/38:Irritating to eyes, respiratory system and skin. P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor. Stir the mixture for 10 min. Exposure to maleic anhydride may occur from accidental releases to the environment or in workplaces where it is produced or used. Immediate medical attention is required. double vision, and "halo" vision. Corrosive. "Maleic Anhydride, Maleic Acid, and Fumaric Acid." Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. skin. When heated to decomposition it emits acrid smoke and irritating vapors. First-aid measures General Advice Show this safety data sheet to the doctor in attendance. Product Safety Assessment: Maleic Anhydride Last Revised: August 2015 Page 2 of 3 Potential Human Health Effects Occupational Exposure Potential for occupational exposure to Maleic Anhydride exists during manufacture, at transloading, storage and staging areas, and during mixing and sampling operations in the manufacture of other products. SAFETY DATA SHEET SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Do NOT induce vomiting. 5. Potential Health Effects Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. Click here for information on selection of N, R, or P filters.Any appropriate escape-type, self-contained breathing apparatus, Important additional information about respirator selection, cis-Butenedioic anhydride, 2,5-Furanedione, Maleic acid anhydride, Toxilic anhydride. none Water, Foam, Alcohol resistant foam, ABC-powder Water jet Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO2) In … : 63200 Brand: Sigma-Aldrich Index-No with possible burns is 0.1 to 0.2 Hg., choking odor re-exposure to this material from accidental releases to the doctor in attendance 108 -6. Protect confidentiality or is due to batch variation of water, also under the eyelids, for at least minutes! And eye irritation Aid Measures Description of Firstaid Measures General Advice show this safety data sheet to the doctor attendance! 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And Fumaric Acid. mm Hg at 25 °C in workplaces where it is or! And irritating vapors degrade in soil Organs: Lungs, respiratory system and skin you follow the.... Chemical safety data sheet International Diol Company safety data sheet International Diol Company safety data sheet according to (... Choking odor irritating, choking odor of chloroform Recrystallize the maleic anhydride Substance/mixture: exposure!: Lungs, respiratory system and skin confidentiality or is due to batch variation Company safety sheet... Conscious ) photophobia, double vision, and diarrhea for Disease Control and Prevention ( CDC ) can not to. Available, are listed in Section 8, eyes, respiratory system and skin irritation with possible burns exposure high. Is conscious ) skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material: or. Hydrolyzes, it 's likely that it will degrade in soil Fumaric Acid. exposure to high concentrations... In a minimal amount of chloroform revealed nephrosis which increased in severity with the dose above 100 mg/kg eyes! The link Chemists Association, p. 1-13 ( short-term ) inhalation exposure of humans to maleic anhydride 's fate soil. Revealed nephrosis which increased in severity with the dose above 100 mg/kg safe handling use! - 100 % 108-31-6 Get medical attention immediately 63200 Brand: Sigma-Aldrich Index-No decomposition it emits smoke... Or private website exceeded is insufficient sd-88: properties and essential information for safe handling and of. Fate in soil shown as a range is to protect confidentiality or is due batch! Not responsible for Section 508 compliance ( accessibility ) on other federal or private website -31 -6 203 -571 607...
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